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The role of the AHR in development of experimental BPD. Hyperoxia is one of major factors that contribute to the development of BPD. Some AHR ligands alleviate the hyperoxia-induced BPD, which may be associated with the activation of many AHR-regulated genes, such as phase I and II enzymes. However, other AHR ligands, such as environmental pollutants, potentiate the hyperoxia-induced BPD.
