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. Author manuscript; available in PMC: 2022 Feb 24.
Published in final edited form as: Chem Rev. 2021 Feb 5;121(4):2545–2647. doi: 10.1021/acs.chemrev.0c01122

Figure 1.

Figure 1.

Schematic representation of the amyloidogenic processing of APP. Aβ is produced by sequential processing of APP by bS and gS to produce either a soluble and nontoxic mixture of Aβ or a more amyloidogenic Aβ mixture with a propensity to form oligomers that bind PrPc and potentially induce AD.