Figure 11.

(A) Schematic representation of two extreme scenarios, the one-step and the two-steps nucleation process for early steps of amyloid aggregation.³⁶⁶ (B) Characteristic steps and kinetics of Aβ42 amyloid proliferation determined experimentally, with the reaction rates at a concentration of 5 microM.³⁷⁰ (C) Description of the dock and lock mechanism, left chart schematically reproduces the results,³⁷⁵ where the evolution of the β-structure of a monomer is followed in time during the dock and lock phases. (D) Effect of hydrodynamic interactions on the aggregation process of Aβ_16–22 peptides (left) and protofibril elongation due to oligomer fusion (right) as observed in LBMD simulations.^366,394