Figure 1.

Regulatory role of SRT1 signaling in the cell. SIRT1, an NAD-dependent deacetylase affects several downstream molecules and promotes life. Sirt1 based downregulation of apoptosis and inflammation leads to the extension of lifespan contrary to that enhanced lipid metabolism and insulin sensitivity are main factors that increase the lifespan. As the discussion included the sirt1 gene and we have a separate section for the associated pathways, Figure 1 was meant to indicate the central role of sirt1 gene in the cellular and metabolic pathways involved in the extended lifespan. Green colour indicates final process regulated, downward and upward arrows indicate downregulation and upregulation of process.