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. 2022 Jan 24;23(3):1314. doi: 10.3390/ijms23031314

Figure 7.

Figure 7

Schematic of the proposed role of EC-sEVs under different FSS condition in ECs. MiRNA profiles in EC-sEVs secreted under atheroprone OSS and atheroprotective LSS conditions are different from each other. Plus, their major regulatory biological processes are involved in angiogenesis, cell adhesion, and inflammatory response in ECs. In addition, LSS-sEVs have anti-inflammatory properties, whereas OSS-sEVs have the opposite effect in ECs.