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Structure of IMA-compounds. (A) Laquinimod (LAQ) is metabolized (N-dealkylation) to form the AHR-active metabolite IMA-06201. Hydrolysis of the prodrug IMA-08401 also forms the IMA-06201 derivative. (B) Tasquinimod (TASQ), its AHR-active metabolite IMA-06504, and the prodrug IMA-07101. (C) Roquinimex (ROQ), its AHR-active metabolite IMA-05101, and the 4-O-benzyl derivative IMA-01403.
