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Upregulation of epidermal differentiation in vitro. Expression analysis of terminal differentiation genes filaggrin (FLG), hornerin (HRNR), involucrin (IVL), and loricrin (LOR) after 48 h stimulation (re-stimulation after 24 h) of monolayer primary human keratinocytes (n = 3) with a concentration series of the IMA-compounds, LAQ, and TCDD. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. Mean +/− SEM.
