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. 2022 Jan 25;23(3):1358. doi: 10.3390/ijms23031358

Figure 5.

Figure 5

Effects of Calycosin on the melanogenesis signaling pathway. (A) Effect of calycosin and H-89 (PKA inhibitor) on melanin content (%) in α-MSH-treated B16F10 cells for 48 h. (B) Effect of calycosin and PD98059 (MAPK/ERK inhibitor) on melanin content (%) in α-MSH-treated B16F10 cells for 48 h. (C) Effect of calycosin and LY294002 (PI3K/Akt inhibitor) on melanin content (%) in α-MSH-treated B16F10 cells for 48 h. (D) Effect of calycosin and SB203580 (p38 inhibitor) on melanin content (%) in α-MSH-treated B16F10 cells for 48 h. Data are represented as the means ± S.D. from three independent experiments. Significant difference versus control: #### p < 0.0001. Significant difference versus α-MSH-treated group: * p < 0.05, *** p < 0.001, **** p < 0.0001.