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. 2022 Feb 1;23(3):1700. doi: 10.3390/ijms23031700

Figure 2.

Figure 2

Pharmacological inhibition of Akt increases INa densities in CA1 hippocampal pyramidal neurons. (A) Representative traces of INa currents recorded from hippocampal neurons treated for 60 min either with DMSO (black) or triciribine 20 µM (red). (B) Current–voltage relationship showing increased peak INa current densities in triciribine-treated hippocampal pyramidal neurons. (C) Peak current density at voltage step of −10 mV in DMSO (n = 8) and triciribine-treated (n = 10) hippocampal neurons. A 60 min treatment with triciribine increased peak sodium current density (*** p = 0.0004 with Student’s t-test). (D,E) Voltage dependence of INa activation (D) and steady-state inactivation (E) of pyramidal cells from DMSO or triciribine-treated hippocampal slices. Treatment with triciribine did not affect neither the voltage dependence of INa activation nor steady-state inactivation. Box plot shows: Range (Perc 25, 75), Mean, Median, Min, and Max. Results are summarized in Table 2.