Table 1.
Effects of triciribine on Nav1.6 properties in HEK-Nav1.6 cells a.
| Treatment | Peak Density (pA/pF) | Activation V1/2 (mV) | kact (mV) | Steady-State Inactivation V1/2 (mV) | kinact (mV) |
|---|---|---|---|---|---|
| DMSO control (n) | −47.8 ± 9.4 (11) | −23.6 ± 1.2 (9) | 3.5 ± 0.3 (9) | −62.9 ± 1.9 (11) | −6.6 ± 0.4 (11) |
| Triciribine 30 µM (n) | −99.4 ± 14.6 (11) ** | −23.5 ± 2.1 (10) | 3.6 ± 0.3 (10) | −59.5 ± 3.1 (8) | −5.8 ± 0.4 (8) |
a Summary of the electrophysiological evaluation of 20 µM triciribine in HEK-Nav1.6 cells. Results are expressed as mean ± SEM. The number of independent experiments is shown in parentheses. A Student’s t-test comparing cells treated with DMSO and 20 µM triciribine was used to determine statistical significance. ** p = 0.0076.