Table 2.
Effects of triciribine on Nav channel properties in CA1 pyramidal cells (slice preparation) a.
| Condition | Peak Density (pA/pF) | Activation V1/2 (mV) | kact (mV) | Inactivation V1/2 (mV) | kinact (mV) |
|---|---|---|---|---|---|
| DMSO control (n) | −49.5 ± 4.5 (8) | −41.4 ± 4.9 (8) | 3.4 ± 0.7 (8) | −54.2 ± 3.5 (7) | −5.6 ± 0.7 (7) |
| Triciribine 20 µM (n) | −99. 4 ± 9.2 *** (10) | −40.3 ± 4.6 (10) | 2.7 ± 0.3 (10) | −53.1 ± 2.3 (6) | −5.4 ± 0.3 (6) |
a Summary of the ex vivo voltage-clamp electrophysiology evaluation of triciribine in pyramidal cells of CA1. Results are expressed as mean ± SEM. The number of independent experiments is shown in parentheses. A Student’s unpaired t-test comparing pyramidal cells treated with 0.1% DMSO and 20 µM triciribine was used to determine statistical significance. ***, p = 0.0004.