Figure 2.

TIA1: gene, isoforms and protein structural details. Schematic representation of human TIA1 gene. Organization of exons and introns of the main isoforms, a and b, generated by alternative splicing, as well as of functional domains of TIA1. TIA1 contains three RNA-recognition motifs (RRMs) and an auxiliary domain rich in asparagine and glutamine (Q/N-rich domain). The amino-acid sequences that differentiate TIA1 a and b isoforms are shown in green. The secondary-tertiary structures of each of the three RRMs are highlighted in the corresponding circles.