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. 2022 Feb 4;23(3):1781. doi: 10.3390/ijms23031781

Table 7.

Compliance of molecules with computational toxicity risk parameters.

Molecules Rate Oral LD50
(g/kg Body Weight)		 Daphnia EC50
(mg/L) *		 Rat Chronic LOAEL
(g/kg Body Weight)		 Fathead Minnow
LC50 (g/L)
Hydroxychloroquine 0.207 34.619 0.033 0.0240
MolPort-009-219-532 0.520 0.011 0.014 0.0006
MolPort-004-996-519 0.867 0.394 0.005 0.0010
MolPort-005-060-605 4.923 0.104 0.005 0.0004
MolPort-005-028-274 5.528 0.370 0.021 0.0010
MolPort-004-042-669 0.819 1.157 0.024 0.0004
MolPort-007-913-111 1.803 0.022 0.051 0.0003
MolPort-002-693-933 1.560 0.442 0.066 0.0002
MolPort-005-083-430 0.063 0.720 0.014 0.0001
MolPort-009-499-144 1.065 2.801 0.016 0.0020

* Daphnia EC50—the effect concentration of a substance that causes adverse effects on 50% of the test population Daphnia magna; Rat chronic —Lowest observed adverse effect level (LOAEL); Fathead minnow—Short-term toxicity to fish.