Table 1.

Interaction energies between doxepin and the H₁ receptor. Averages and standard errors of mean ($n=10,000$ frames from the second half of the simulations) were calculated for the binding energies using MM/GBSA. Values are averaged over two independent simulation runs for each system.

System	Binding Energy [kcal·mol−1]
H1R-D	−34.52 ± 0.04
H1R-DS	−33.71 ± 0.05
H1R-DSP	−33.81 ± 0.03