Table 1.
TEG® 5000 and ROTEM® delta “legacy device” parameters and reference ranges [7,27,35,37,38,42,43,44,45,46,47,48,49,50,51,52].
| Parameter | TEG® 5000 Analyzer 1 | ROTEM® Delta Analyzer |
|---|---|---|
| Clot initiation: the time from the test start to amplitude = 2 mm | R (Kaolin)/ACT (rTEG®) Kaolin: 4.6–9.1 min rTEG®: 86–118 s |
CT INTEM: 137–246 s EXTEM: 42–74 s |
| Clot formation and clot kinetics: the time taken to achieve a level of clot strength, amplitude = 20 mm | K Kaolin: 0.8–2.1 min rTEG®: 1–2 min |
CFT INTEM: 40–100 s EXTEM: 46–148 s |
| Angle of clot formation | α-angle Kaolin: 53–72° rTEG®: 64–80° |
α-angle INTEM: 71–82° EXTEM: 63–81° |
| Maximum clot strength | MA Kaolin: 50–70 mm rTEG®: 52–71 mm MAff/CFF: 15–32 mm |
MCF INTEM: 52–72 mm EXTEM: 49–71 mm FIBTEM: 9–25 mm |
| Lysis 2 TEG®: rate of clot breakdown 30 min after MA is reached. ROTEM®: the residual % of MCF amplitude when measured 30 min after CT (CLI30); the % reduction MCF amplitude at a given timepoint (ML) |
LY30 Kaolin: 0–7.5% rTEG®: 0–7.5% |
CLI30: 94–100% ML: <15% |
Abbreviations: activated clotting time (ACT); clot formation time (CFT); clot lysis index at 30 min (CLI30); clotting time (CT); extrinsic thromboelastometry (EXTEM); fibrin-based thromboelastometry (FIBTEM); intrinsic thromboelastometry (INTEM); kinetics (K); lysis at 30 min (LY30); maximum amplitude (MA); maximum clot firmness (MCF); maximum lysis (ML); RapidTEG (rTEG®); reaction time (R); rotational thromboelastometry (ROTEM®); thromboelastography (TEG®); TEG functional fibrinogen (MAff/CFF). 1 For the TEG® 6s and the TEG® 5000, the manufacturer (Haemonetics, Braintree, Massachusetts) makes clear that the ranges are interchangeable, but that any difference in the values is a consequence of the Clinical and Laboratory Standards Institute (CLSI) methodology used for the TEG® 6s values. Additionally, the manufacturer’s ranges are not globally prescriptive, as every laboratory must establish their own reference intervals [48]. 2 The values for clinically significant fibrinolysis vary greatly in the literature.