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Schematic illustration of contrast enhancements in the tumor site via enhanced permeability and retention (EPR) and GlcN effects. The PAA-UGONs allow only the EPR effects whereas the GlcN-PAA-UGONs allow the EPR and GlcN effects. Consequently, GlcN-PAA-UGONs provide the enhanced tumor imaging via the additional GlcN effects, compared with PAA-UGONs.
