Table 1.
Clinical and echocardiographic variables at rest in both groups.
| Variables | All Patients (n = 101) | G1: CR-GLS Present (n = 56 pts) | G2: CR-GLS Absent (n = 45 pts) | p Value |
|---|---|---|---|---|
| Age (years) | 69.06 ± 12 | 66.54 ± 14.10 | 72.72 ± 8.52 | 0 |
| Gender (male) | 54 (53.5%) | 33 (58.9%) | 21 (46.7%) | 0.21 |
| HTN | 61 (60.4%) | 30 (53.6%) | 31 (68.9%) | 0.11 |
| Prior MI without dyssynergies | 3 (3%) | 0 (0%) | 3 (6.7%) | 0.051 |
| Prior PCI | 2 (2%) | 0 (0%) | 2 (4.4%) | 0.11 |
| Prior CABG | 10 (9.9%) | 6 (10.7%) | 4 (8.9%) | 0.76 |
| ACE Inh/ARB II | 74 (73.3%) | 41 (73.2%) | 33 (73.3%) | 0.98 |
| Betablockers | 40 (39.6%) | 18 (32.1%) | 22 (48.9%) | 0.087 |
| Calcium antagonists | 40 (39.6%) | 22 (39.3%) | 18 (40%) | 0.94 |
| Statins | 32 (31.7%) | 17 (30.4%) | 15 (33.3%) | 0.74 |
| SBP at rest (mmHg) | 117.47 ± 6.18 | 117.2 ± 6.6 | 117.7 ± 5.59 | 0.66 |
| HR at rest (bpm) | 64 ± 6.15 | 64.6 ± 6.2 | 63.35 ± 6 | 0.29 |
| Bicuspid Ao | 20 (19.8%) | 15 (26.8%) | 5 (11.1%) | 0.049 |
| AVA (cm2) indexed at rest | 0.46 ± 0.39 | 0.49 ± 0.03 | 0.44 ± 0.035 | <0.001 |
| LV Mass (g) | 132 ± 19 | 133 ± 18.5 | 131.5 ± 19.8 | 0.67 |
| Peak Ao velocity at rest (m/s) | 4.58 ± 0.31 | 4.43 ± 0.28 | 4.78 ± 0.22 | <0.001 |
| Peak Ao gradient at rest (mmHg) | 84. 54 ± 11.59 | 78.89 ± 10.6 | 91.58 ± 8.58 | <0.001 |
| Medium Ao gradient at rest (mmHg) | 42.49 ± 5.9 | 39.8 ± 5.7 | 45.8 ± 4.3 | <0.001 |
| LVEF at rest (%) | 63.23 ± 5.8 | 64 ± 5.6 | 62.1 ± 5.9 | 0.77 |
| GLS at rest (%) | −18.79 ± 2.12 | −19.14 ± 2.19 | −18.37 ± 1.98 | 0.70 |
| E/e’ at rest (cm/seg) | 12.5 ± 4.7 | 12.3 ± 5 | 12.86 ± 4.5 | 0.60 |
| PASP at rest (mmHg) | 34.73 ± 7.5 | 34 ± 7.3 | 35.4 ± 7.8 | 0.40 |
Continuous variables are presented as mean ± SD. Categorical variables are expressed as number (percentage). HTN = hypertension, MI = myocardial infarction, PCI = percutaneous coronary interventions, CABG = coronary artery bypass grafting, ACE Inh = angiotensin converting enzyme inhibitors, ARB II = angiotensin II receptor blockers, AVA = aortic valve area, Ao = aortic, LVEF = ejection fraction, GLS = global longitudinal strain, CR = contractile reserve, PSP = pulmonary systolic pressure, FBPR = flat blood pressure response, SBP = systolic blood pressure, HR = heart rate, LV = left ventricle.