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A proposed working model for CCF formation and activation of cGAS to promote breast cancer metastasis. In the highly metastatic breast cancer cells, EZH2 promotes the formation of CCF dependent on HMGA1, and the stability of EZH2 requires USP7. The activation of cGAS by EZH2 via CCF requires USP7 to deubiquitinate cGAS and stabilize cGAS. EZH2-CCF-cGAS axis can promote breast cancer metastasis, and targeting this axis with inhibitors can inhibit breast cancer metastasis.
