Table 1.
List of semiquantitative parameters and of radiomics features considered in the study.
| Semiquantitave Parameters |
|---|
| SUV-related |
| SUVmax |
| SUVmean |
| SUVlbm |
| SUVbsa |
| Volumetric parameters |
| MTV |
| TLG |
| Radiomics features |
| First order features |
| Histogram related |
| Histo skewness |
| Histo kurtosis |
| Histo excess kurtosis |
| Histo entropy_log10 |
| Histo entropy_log2 |
| Histo energy |
| Shape related |
| Shape volume_mL |
| Shape volume_vx |
| Shape sphericity |
| Shape compacity |
| Second order features |
| Grey level co-occurrence matrix (GLCM) related |
| GLCM homogeneity |
| GLCM energy |
| GLCM contrast |
| GLCM correlation |
| GLCM entropy_log10 |
| GLCM entropy_log2 |
| GLCM dissimilarity |
| Grey-level run length matrix (GLRLM) related |
| GLRLM SRE |
| GLRLM LRE |
| GLRLM LGRE |
| GLRLM HGRE |
| GLRLM SRLGE |
| GLRLM SRHGE |
| GLRLM LRLGE |
| GLRLM LRHGE |
| GLRLM GLNU |
| GLRLM RLNU |
| GLRLM RP |
| Neighborhood grey level different matrix (NGLDM) related |
| NGLDM coarseness |
| NGLDM contrast |
| NGLDM busyness |
| Grey-level zone length matrix (GLZLM) related |
| GLZLM SZE |
| GLZLM LZE |
| GLZLM LGZE |
| GLZLM HGZE |
| GLZLM SZLGE |
| GLZLM SZHGE |
| GLZLM LZLGE |
| GLZLM LZHGE |
| GLZLM GLNU |
| GLZLM ZLNU |
| GLZLM ZP |
SUVmax: standardized uptake value body weight max; SUVmean: standardized uptake value body weight mean; SUVlbm: standardized uptake value lean body mass, SUVbsa: standardized uptake value body surface area; MTV: metabolic tumor volume; TLG: total lesion glicolysis; SRE: short-run emphasis; LRE: long-run emphasis; LGRE: Low Gray-level Run Emphasis; HGRE: High Gray-level Run Emphasis; SRLGE: Short-Run Low Gray-level Em-phasis; SRHGE: Short-Run High Gray-level Emphasis; LRLGE: Long-Run Low Gray-level Emphasis; LRHGE: Long-Run High Gray-level Emphasis; GLNU: Gray-Level Non-Uniformity; RLNU: Run Length Non-Uniformity; RP: Run Percentage; SZE: Short-zone emphasis; LZE: Long-zone emphasis; LGZE: Low Gray-level Zone Emphasis; HGZE: High Gray-level Zone Emphasis; SZLGE: Short-Zone Low Gray-level Emphasis; SZHGE: Short-Zone High Gray-level Em-phasis; LZLGE: Long-Zone Low Gray-level Emphasis; LZHGE: Long-Zone High Gray-level Emphasis; ZLNU: Zone Length Non-Uniformity.Extraction of RF by LIFEx is only possible for VOI of at least 64 voxels, therefore 16 patients were excluded from the study because the volume of the TIs uptake was below this limit. As a consequence, the final number of patients included in the study was 221.