Table 5.
Bivariate analysis for clinical, semiquantitative PET/CT parameters and radiomics features for the single scanner and for both scanners considered together. For each analysis, only the couples with best performances are reported.
| Covariate 1 | Covariate 2 | Mean p-Value 1 | Mean p-Value 2 | Mean AUC |
|---|---|---|---|---|
| Scanner 1 | ||||
| GLZLM GLNU | MTV | <0.01 | 0.01 | 0.779 |
| GLRLM RLNU | MTV | 0.02 | 0.03 | 0.776 |
| GLCM energy | GLCM entropy_log2 | 0.04 | <0.01 | 0.771 |
| GLCM energy | GLCM entropy_log10 | 0.04 | <0.01 | 0.771 |
| GLCM entropy_log2 | GLRLM HGRE | 0.01 | 0.03 | 0.763 |
| GLCM entropy_log10 | GLZLM HGZE | 0.02 | 0.02 | 0.762 |
| GLCM entropy_log10 | GLRLM HGRE | 0.01 | 0.03 | 0.761 |
| GLCM entropy_log2 | GLZLM HGZE | 0.02 | 0.02 | 0.760 |
| GLCM entropy_log10 | GLZLM SZHGE | 0.01 | 0.02 | 0.760 |
| GLCM entropy_log2 | GLZLM SZHGE | 0.01 | 0.02 | 0.759 |
| GLRLM RP | GLZLM SZHGE | 0.04 | 0.02 | 0.751 |
| GLRLM HGRE | GLRLM RP | 0.02 | 0.03 | 0.745 |
| MTV | TLG | <0.01 | 0.01 | 0.741 |
| GLRLM SRE | GLZLM HGZE | 0.03 | 0.01 | 0.740 |
| NGLDM coarseness | NGLDM busyness | <0.01 | 0.01 | 0.738 |
| Shape volume_mL | GLRLM GLNU | 0.03 | 0.01 | 0.736 |
| GLRLM GLNU | NGLDM coarseness | 0.03 | <0.01 | 0.734 |
| GLRLM SRE | GLZLM SZHGE | 0.03 | 0.02 | 0.732 |
| GLRLM SRE | GLRLM HGRE | 0.03 | 0.02 | 0.730 |
| GLRLM LRLGE | NGLDM coarseness | <0.01 | 0.04 | 0.730 |
| Shape volume_vx | GLRLM GLNU | 0.02 | 0.02 | 0.723 |
| GLCM entropy_log10 | GLZLM SZHGE | 0.04 | <0.01 | 0.713 |
| Shape compacity | GLZLM GLNU | 0.01 | <0.01 | 0.707 |
| Shape volume_mL | MTV | 0.02 | 0.02 | 0.693 |
| Ultrasound dimension | MTV | 0.01 | 0.02 | 0.691 |
| GLCM correlation | NGLDM coarseness | <0.01 | <0.01 | 0.690 |
| Shape compacity | NGLDM coarseness | 0.03 | 0.01 | 0.680 |
| Ultrasound dimension | GLRLM GLNU | 0.01 | 0.01 | 0.677 |
| Scanner 2 | ||||
| GLRLM SRE | SUVmean | 0.04 | 0.01 | 0.712 |
| GLCM entropy_log10 | SUVbsa | 0.05 | 0.01 | 0.697 |
| GLCM entropy_log2 | SUVbsa | 0.05 | 0.02 | 0.696 |
| GLCM entropy_log2 | GLZLM SZHGE | 0.03 | 0.02 | 0.689 |
| GLCM entropy_log10 | GLZLM SZHGE | 0.03 | 0.02 | 0.689 |
| GLRLM RP | SUVmean | 0.05 | 0.02 | 0.686 |
| GLCM entropy_log2 | GLZLM HGZE | 0.05 | 0.02 | 0.682 |
| GLCM entropy_log10 | GLZLM HGZE | 0.05 | 0.02 | 0.680 |
| GLCM entropy_log10 | GLRLM HGRE | 0.04 | 0.02 | 0.679 |
| GLCM energy | GLRLM LRHGE | 0.01 | 0.02 | 0.679 |
| GLCM entropy_log2 | GLRLM HGRE | 0.04 | 0.02 | 0.679 |
| NGLDM coarseness | GLZLM ZP | 0.03 | <0.01 | 0.677 |
| Histo energy | GLRLM HGRE | 0.04 | 0.03 | 0.676 |
| GLCM homogeneity | NGLDM coarseness | <0.01 | 0.06 | 0.675 |
| GLCM contrast | GLCM entropy_log10 | 0.04 | 0.04 | 0.673 |
| GLCM contrast | GLCM entropy_log2 | 0.04 | 0.04 | 0.673 |
| Histo energy | GLZLM SZHGE | 0.04 | 0.03 | 0.669 |
| GLRLM SRE | GLRLM HGRE | 0.04 | 0.03 | 0.669 |
| GLRLM SRE | NGLDM coarseness | 0.01 | 0.05 | 0.668 |
| GLRLM LRE | SUVmean | 0.04 | 0.01 | 0.668 |
| NGLDM coarseness | NGLDM busyness | 0.02 | 0.02 | 0.666 |
| GLZLM GLNU | MTV | 0.02 | 0.02 | 0.663 |
| GLCM energy | GLZLM SZHGE | 0.06 | <0.01 | 0.660 |
| GLCM energy | GLRLM HGRE | 0.06 | <0.01 | 0.659 |
| GLRLM RP | NGLDM coarseness | 0.01 | 0.05 | 0.657 |
| GLRLM RLNU | MTV | 0.01 | 0.01 | 0.650 |
| NGLDM coarseness | MTV | 0.04 | 0.03 | 0.627 |
| Scanner 1 + 2 | ||||
| GLCM entropy_log2 | GLZLM SZHGE | <0.01 | <0.01 | 0.769 |
| GLCM entropy_log10 | GLRLM HGRE | <0.01 | <0.01 | 0.769 |
| GLCM entropy_log10 | GLZLM SZHGE | <0.01 | <0.01 | 0.769 |
| GLCM entropy_log10 | GLZLM HGZE | <0.01 | <0.01 | 0.769 |
| GLCM entropy_log2 | GLRLM HGRE | <0.01 | <0.01 | 0.768 |
| GLCM entropy_log2 | GLZLM HGZE | <0.01 | <0.01 | 0.768 |
| GLRLM SRE | SUVmean | <0.01 | <0.01 | 0.763 |
| GLRLM GLNU | NGLDM Coarseness | <0.01 | <0.01 | 0.756 |
| GLCM homogeneity | GLRLM HGRE | <0.01 | <0.01 | 0.749 |
| GLCM homogeneity | GLZLM HGZE | <0.01 | <0.01 | 0.749 |
| Histo energy | GLRLM HGRE | <0.01 | <0.01 | 0.749 |
| Histo energyUniformity | GLZLM SZHGE | <0.01 | <0.01 | 0.748 |
| GLCM homogeneity | GLZLM SZHGE | <0.01 | <0.01 | 0.748 |
| NGLDM coarseness | NGLDM busyness | <0.01 | <0.01 | 0.746 |
| GLRLM SRE | GLRLM HGRE | <0.01 | <0.01 | 0.742 |
| GLRLM RP | GLZLM HGZE | <0.01 | <0.01 | 0.742 |
| GLRLM SRE | GLZLM HGZE | <0.01 | <0.01 | 0.742 |
| GLRLM HGRE | GLRLM RP | <0.01 | <0.01 | 0.742 |
| NGLDM coarseness | GLZLM ZP | <0.01 | <0.01 | 0.741 |
| GLZLM GLNU | MTV | <0.01 | <0.01 | 0.738 |
| GLRLM SRE | GLZLM SZHGE | <0.01 | <0.01 | 0.738 |
| GLRLM RP | GLZLM SZHGE | <0.01 | <0.01 | 0.737 |
| GLRLM LRE | GLRLM LRHGE | <0.01 | <0.01 | 0.737 |
| GLRLM RLNU | MTV | <0.01 | <0.01 | 0.730 |
| Histo energy | GLCM energy | <0.01 | <0.01 | 0.717 |
| Shape compacity | NGLDM coarseness | <0.01 | <0.01 | 0.681 |
| GLCM correlation | NGLDM coarseness | <0.01 | <0.01 | 0.654 |
| Shape compacity | GLZLM GLNU | <0.01 | <0.01 | 0.640 |
AUC: area under the curve.