Table 2.

Representative transport substrates for ATP-Binding Cassette (ABC) and Solute Carrier (SLC) transporters at the Blood-Brain Barrier (BBB).

Transporter	Representative Centrally Active Transport Substrates
OATPs/Oatps (SLCOs/Slcos)	HMG CoA Reductase Inhibitors (i.e., statins; atorvastatin, pravastatin, rosuvastatin) [5,96] Prostaglandin E2 [96] Estrone-3-Sulfate, Dihydroepiandrosterone Sulfate (DHEAS), Estradiol-17β-Glucuronide [97]
OCTs/Octs (SLC22A/Slc22a)	Memantine [5] Pramipexole, Selegiline, Varenicline [6] Amisulpride [98] Metformin [99]
MATE1/Mate1 (SLC47A1/Slc47a1)	Metformin, Thiamine, Topotecan [96] Amisulpride [98]
P-gp (MDR1/Mdr1) (ABCB1/Abcb1a/Abcb1b)	Amitriptyline, Cyclosporine A, Lapatinib, Losartan, Lovastatin, Phenytoin, Tetracycline, Verapamil [96] Atorvastatin, Rosuvastatin [100] Tacrolimus, Rifampicin [29]
BCRP/Bcrp (ABCG2/Abcg2)	Coumestrol, Daidzein, Dantrolene, Dipyridamole, Estradiol-17β-Glucuronide, Genistein, Glyburide, Lapatinib [96] Atorvastatin, Pravastatin, Rosuvastatin [100] Estrone-3-Sulfate, Dihydroepiandrosterone Sulfate (DHEAS), Dihydrotestosterone (DHT) [97]
MRPs/Mrps (ABCC/Abcc)	Glutathione (GSH), GSH Conjugates, GSSG [5] Estradiol-17β-Glucuronide [96] Estrone-3-Sulfate, Dihydroepiandrosterone Sulfate (DHEAS) [97]