Table 10.
Micropuncture studies of acute hyperkalemia in the rat
| Control |
Acute KCl |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Wright et al. (30), µmol/min/100 g body wt | |||||||||
| PCT | DT | CD | Urine | PCT | DT | CD | Urine | ||
| Absolute delivery | Absolute delivery | ||||||||
| Na+ | 69.5 | 4.5 | 1.6 | 0.4 | Na+ | 55.0 | 5.2 | 2.7 | 1.4 |
| K+ | 1.90 | 0.29 | 0.44 | 0.38 | K+ | 3.94 | 1.18 | 1.97 | 2.44 |
| Delivery relative to PCT delivery | Delivery relative to PCT delivery | ||||||||
| Na+ | 100.0% | 6.5% | 2.3% | 0.6% | Na+ | 100.0% | 9.5% | 4.9% | 2.5% |
| K+ | 100.0% | 15.3% | 23.2% | 20.0% | K+ | 100.0% | 29.9% | 50.0% | 61.9% |
| Absolute reabsorption | Absolute reabsorption | ||||||||
| Na+ | 65.0 | 2.9 | 1.2 | Na+ | 49.8 | 2.5 | 1.3 | ||
| K+ | 1.61 | −0.15 | 0.06 | K+ | 2.76 | −0.79 | −0.47 | ||
| Reabsorption relative to PCT delivery | Reabsorption relative to PCT delivery | ||||||||
| Na+ | 93.5% | 4.2% | 1.7% | Na+ | 90.5% | 4.5% | 2.4% | ||
| K+ | 84.7% | −7.9% | 3.2% | K+ | 70.1% | −20.1% | −11.9% | ||
| Karlmark et al. (31) and Jaeger et al. (32), µmol/min/320 g body wt | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| PCT | DT | CD | Urine | PCT | DT | CD | Urine | ||
| Absolute delivery | Absolute delivery | ||||||||
| Na+ | 361.1 | 28.2 | 13.7 | 3.3 | Na+ | 306.6 | 27.0 | 16.2 | 0.4 |
| K+ | 9.74 | 1.27 | 1.95 | 1.87 | K+ | 17.32 | 3.3 | 7.1 | 5.26 |
| 1.29 | 1.07 | 0.81 | 0.68 | ||||||
| Delivery relative to PCT delivery | Delivery relative to PCT delivery | ||||||||
| Na+ | 7.8% | 3.8% | 1.1% | Na+ | 8.8% | 5.3% | 0.2% | ||
| K+ | 13% | 20% | 22% | K+ | 19% | 41% | 41% | ||
| Absolute reabsorption | Absolute reabsorption | ||||||||
| Na+ | 332.9 | 14.4 | 10.4 | Na+ | 279.6 | 10.7 | 15.8 | ||
| K+ | 8.47 | −0.68 | 0.08 | K+ | 14.03 | −3.81 | 1.84 | ||
| Reabsorption relative to PCT delivery | Reabsorption relative to PCT delivery | ||||||||
| Na+ | 92.2% | 4.0% | 2.9% | Na+ | 91.2% | 3.5% | 5.2% | ||
| K+ | 87.0% | −7.0% | 0.8% | K+ | 81.0% | −22.0% | 10.6% | ||
| Sufit and Jamison (33), µmol/min/160 g body wt | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| PCT | LOH | DT | Urine | PCT | LOH | DT | Urine | ||
| Absolute delivery | Absolute delivery | ||||||||
| Na+ | 143.0 | 85.8 | 15.7 | 0.21 | Na+ | 167.0 | 93.5 | 18.4 | 1.32 |
| K+ | 4.00 | 2.64 | 0.68 | 0.25 | K+ | 7.08 | 4.46 | 1.84 | 3.33 |
| Delivery relative to PCT delivery | Delivery relative to PCT delivery | ||||||||
| Na+ | 60% | 11% | 0.2% | Na+ | 56% | 11% | 0.8% | ||
| K+ | 66% | 17% | 6.2% | K+ | 63% | 26% | 47.1% | ||
| Absolute reabsorption | Absolute reabsorption | ||||||||
| Na+ | 57.2 | 70.1 | 15.5 | Na+ | 73.5 | 75.2 | 17.1 | ||
| K+ | 1.36 | 1.96 | 0.43 | K+ | 2.62 | 2.62 | −1.49 | ||
| Reabsorption relative to PCT delivery | Reabsorption relative to PCT delivery | ||||||||
| Na+ | 40.0% | 49.0% | 10.9% | Na+ | 44.0% | 45.0% | 10.2% | ||
| K+ | 34.0% | 49.0% | 10.8% | K+ | 37.0% | 37.0% | −21.1% | ||
CD, collecting duct; DT, distal tubule; LOH, loop of Henle; PCT, proximal convoluted tubule. For studies in which absolute delivery has been reported. This table shows calculated delivery relative to filtered load; for studies in which relative delivery is reported, then the absolute flows and fluxes were calculated. For each study, the reported values are shown in bold.