Table 2.

Differences between NBCe1-A KO and PT-NBCe1-A/B KO in the cortex

Protein	NBCe1-A KO (19)		PT-NBCe1-A/B KO (Present Study)
PDG	Basal Diet	Acid Diet	Basal Diet	Acid Diet
	Less in KO mice	Less in KO mice	Less in KO mice	Less in KO mice
	Acid loading increased expression in both WT and KO mice		Acid loading increased expression in WT mice but not in KO mice*
PEPCK	Basal Diet	Acid Diet	Basal Diet	Acid Diet
	Less in KO mice	Less in KO mice	Less in KO mice	Less in KO mice
	Acid loading increased expression in both WT and KO mice but less in KO mice		Acid loading increased expression in both WT and KO mice
GS	Basal Diet	Acid Diet	Basal Diet	Acid Diet
	No effect of KO	Greater expression in KO mice	Greater expression in KO mice*	Greater expression in KO mice
	Acid loading decreased expression in both WT and KO mice, but the decrease was less in KO mice than in WT mice		Acid loading decreased expression in WT mice but not in KO mice*

GS, glutamine synthetase; KO, knockout; NBCe1, Na⁺-bicarbonate cotransporter, electrogenic, isoform 1; PDG, phosphate-dependent glutaminase; PEPCK, phosphoenolpyruvate carboxykinase; WT, wild type.

*Difference between NBCe1-A deletion [NBCe1-A knockout (KO)] and proximal tubule (PT)-specific NBCe1 deletion (PT-NBCe1-A/B KO).