Table 3.

Differences between NBCe1-A and PT-NBCe1-A/B KO in the OSOM

Protein	NBCe1-A KO (19)		PT-NBCe1-A/B KO (Current Study)
PDG	Basal Diet	Acid Diet	Basal Diet	Acid Diet
	WT and KO mice did not differ	WT and KO mice did not differ	WT and KO mice did not differ	Less expression in KO mice*
	Acid loading increased expression in both WT and KO mice		Acid loading increased expression in WT mice but not in KO mice*
PEPCK	Basal Diet	Acid Diet	Basal Diet	Acid Diet
	WT and KO mice did not differ	Greater in KO mice than in WT mice	WT and KO mice did not differ	WT and KO mice did not differ*
	Acid loading increased expression in both WT and KO mice; the increase was greater in KO mice than in WT mice		Increase in expression did not differ between WT and KO mice*
GS	Basal Diet	Acid Diet	Basal Diet	Acid Diet
	WT and KO mice did not differ	Decreased by KO	Increased by KO*	Increased by KO*
	Acid loading decreased expression in both WT and KO mice; the difference was greater in KO mice		Acid loading decreased expression in WT mice but not in KO mice*

GS, glutamine synthetase; KO, knockout; NBCe1, Na⁺-bicarbonate cotransporter, electrogenic, isoform 1; OSOM, outer stripe of the outer medulla; PDG, phosphate-dependent glutaminase; PEPCK, phosphoenolpyruvate carboxykinase; PT, proximal tubule; WT, wild type.

*Difference between NBCe1-A deletion [NBCe1-A knockout (KO)] and proximal tubule (PT)-specific NBCe1 deletion (PT-NBCe1-A/B KO).