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. 2022 Jan 25;11(3):587. doi: 10.3390/jcm11030587

Figure 4.

Figure 4

Binding ability of COVID-19 spike subunits to native and glycated albumin in vitro. Representative Western blots show the binding of recombinant SARS-CoV-2 spike protein S1 subunit to 1 g/dL and 3.5 g/dL native albumin. Experiments where each final albumin concentration of native albumin (1 g/dL and 3.5 g/dL) was replaced by glycated albumin (25% and 50%) are also represented. The figure also shows a representative Western blot showing the binding of native albumin (1 g/dL and 3.5 g/dL) to the recombinant receptor-binding region, RBD, of the SARS-CoV-2 spike protein contained in the S1 subunit. The spike protein S2 subunit failed to bind to 1 g/dL and 3.5 g/dL albumin.