Figure 5.

Effects of subanesthetic doses of IV ketamine infusion on BGluM of female rats. (A) Representative images of ¹⁸F-FDG-PET/CT of a rat brain. Three images including sagittal, planar, and coronal sections from left to right are shown in the first image. The second image shows a coronal section with a rat brain atlas registered to it. (B) Both 10 and 20 mg/kg ketamine increased BGluM in the cortex. (C) The 10 mg/kg dose reduced BGluM in the thalamus. (D) The 20 mg/kg dose reduced BGluM in the hypothalamus. (E) Both 10 and 20 mg/kg ketamine doses reduced BGluM in the midbrain. Baseline BGluM levels in these brain regions are not significantly different between the groups as shown in scan 1. * p < 0.05 compared to saline controls.