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. 2022 Feb 8;23(3):1911. doi: 10.3390/ijms23031911

Figure 1.

Figure 1

AKR1B10 is among the most frequently overexpressed genes in post-mortem lungs from severe COVID-19 patients. (A) Volcano plot showing the differential gene expression in lung tissue from deceased COVID-19 patients vs. healthy donors, reduced to genes over- or under-expressed with an FDR < 0.02 (from available transcriptomic data [28]). ● corresponds to an adjusted p-value < 0.001; ● corresponds to a fold change > 5; and ● corresponds to both. (B) GeneSet Enrichment Analysis (GSEA) plots of two genesets associated with the respective Gene Ontology terms CYTOKINE_PRODUCTION (NES: 6.18; FDR < 0.001) and POSITIVE_REGULATION_OF_INFLAMMATORY_RESPONSE (NES: 7.79; FDR < 0.001) illustrating two major components of the transcriptomic signature in lungs from severe COVID-19 patients.