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. 2022 Feb 8;23(3):1911. doi: 10.3390/ijms23031911

Figure 2.

Figure 2

AKR1B10 concentration in sera is tightly associated with COVID-19 severity and correlated with other biological parameters known to be related to cytokine storm. (A) ELISA dosages of AKR1B10 in the blood of COVID-19 patients stratified into three groups corresponding to: “Non-COVID” (patients without COVID-19; n = 16, including 6 healthy individuals, 4 COPD and 6 cancer patients); “Non-ICU” (patients hospitalised in a non-ICU respiratory ward; n = 61), and “ICU” (patients admitted in an Intensive Care Unit; n = 43); (B) respective balanced proportions of patients of the non-COVID, non-ICU and ICU groups in each of the four quartiles (from Q1, the lowest, to Q4 the highest) of AKR1B10 sera concentrations; (C) correlations between AKR1B10 concentrations and Lymphocyte counts, CRP or LDH levels in the blood of COVID-19 patients. LDH: Lactate Dehydrogenase; Lympho: Lymphocyte counts; #: difference compared to Non-COVID individuals (###: p < 0.001); *: difference compared to non-ICU patients (**: p < 0.01).