Table 3.
Correlations of serum GDF15 levels with anthropometric, metabolic, infectious and treatment factors in PLWH.
| Serum GDF15 (pg/L) (Crude Analysis) | Age-Adjusted Serum GDF15 | |||
|---|---|---|---|---|
| r | p | r | p | |
| Age | 0.453 | <0.001 | ||
| Fasting insulin | 0.327 | <0.001 | 0.280 | 0.002 |
| HOMA1-IR | 0.326 | <0.001 | 0.272 | 0.003 |
| FGF21 | 0.422 | <0.001 | 0.425 | <0.001 |
| MUFAs | 0.479 | <0.001 | 0.417 | <0.001 |
| PUFAs | −0.492 | <0.001 | −0.468 | <0.001 |
| LDL cholesterol | −0.212 | 0.047 | −0.278 | 0.003 |
| Diastolic BP | 0.241 | 0.006 | 0.243 | 0.009 |
| Years of infection | 0.513 | <0.001 | 0.459 | <0.001 |
| NRTI exposure | 0.575 | <0.001 | 0.434 | <0.001 |
| NNRTI exposure | 0.151 | 0.002 | 0.141 | 0.372 |
| PI exposure | 0.417 | <0.001 | 0.392 | <0.001 |
| Interleukin-6 | 0.1882 | 0.031 | 0.285 | 0.013 |
| Interleukin-8 | 0.424 | <0.001 | 0.371 | <0.001 |
| TNF-α | 0.329 | 0.004 | 0.215 | 0.003 |
| Leptin | −0.165 | 0.063 | −0.203 | 0.029 |
| C reactive protein | 0.289 | 0.001 | 0.318 | 0.001 |
| Framingham CVR | 0.377 | <0.001 | 0.152 | 0.105 |
Significant correlations are highlighted in bold. n = 152. BP = blood pressure, LDL = low density lipoprotein, MUFA = monounsaturated fatty acids, PUFA = polyunsaturated fatty acids, HOMA1-IR, homeostasis model assessment of insulin resistance 1, FGF21 = fibroblast growth factor 21, GDF15 = growth differentiation factor 15, NRTI = nucleoside reverse transcriptase inhibitor, NNRTI = non-nucleoside reverse transcriptase inhibitor, PI = protease inhibitor, TNF-α = tumor necrosis factor alpha, CVR = cardiovascular risk.