Figure 1.

Murine soluble amyloid beta 42 oligomer (sAβO42) exerted negligible and disruptive effects on the barrier function of a bEnd.3 monolayer up to 40 µM. (A) Identification for the sizes of the prepared Aβ42 peptides using SDS-PAGE electrophoresis with Coomassie brilliant blue staining. (B) The cell viability and (C) the relative levels of reactive oxygen species (ROS) in bEnd.3 cells treated with sAβO42 (1–40 µM) for 24 h. Data are shown as means ± SD of at least three independent experiments and were analyzed by one-way ANOVA followed by a post hoc Dunnett’s test. * p ≤ 0.1, *** p ≤ 0.001, **** p ≤ 0.0001 vs. control group.