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. 2022 Feb 7;23(3):1878. doi: 10.3390/ijms23031878

Figure 9.

Figure 9

(A) Astrocyte secretion stimulated by sAβO42 (ACM-sAβO42) induced significant downregulation of the protein levels of ZO 1 and claudin-5 in a dose-dependent manner. The protein expression level of ZO-1 and claudin-5 upon the exposure of ACM-sAβO42 (5–40 µM for 24 h). (B) Fluorescent intensity of junctional proteins ZO-1 and claudin-5 in bEnd.3 cells induced by sAβO42 (10 µM) and ACM-sAβO42 (10 µM). Data are shown as means ± SD of at least three independent experiments and were analyzed by one-way ANOVA followed by a post hoc Dunnett’s test. * p ≤ 0.1, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001 vs. control group.