Figure 1.

Classification used to differentiate primary and secondary hemolytic uremic syndromes according to the probability of complement-mediation. Orange: demonstrated or highly plausible complement-mediation. Pastel orange: complement-mediation highly plausible or demonstrated in a subset of patients. Blue: no evidence of complement-mediation in HUS. Abbreviations: DGKE, diacylglycerol kinase ε; HSCT: hematopoietic stem cell transplantation; HUS, hemolytic uremic syndrome; SOT, solid organ transplantation; STEC HUS, shiga-toxin Escherichia coli hemolytic uremic syndrome.