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. 2022 Jan 2;21(1):33–48. doi: 10.1080/15384101.2021.2010170

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Figure 1. — C-28/I2 chondrocyte cell senescence model was established by H₂O₂ treatment. (a) Sa-β-gal-positive cells were significantly up-regulated under H₂O₂ treatment. (b) H₂O₂ treatment reduced cell proliferation of C-28/I2. (c) The effect of H₂O₂ treatment on cell cycle phase by Flow cytometry analysis. (d) H₂O₂ (30 μmol/L) resulted in slight C-28/I2 chondrocyte apoptosis by Flow cytometry analysis. (e) The expression of P21 and P16 was increased under H₂O₂. (f). IL-1β and IL-6 expression was increased in the H₂O₂-induced C-28/I2 chondrocyte cell senescence model. Data are expressed as mean ± SD. The asterisk indicates a significant difference (p < 0.05).

Figure 1. — C-28/I2 chondrocyte cell senescence model was established by H₂O₂ treatment. (a) Sa-β-gal-positive cells were significantly up-regulated under H₂O₂ treatment. (b) H₂O₂ treatment reduced cell proliferation of C-28/I2. (c) The effect of H₂O₂ treatment on cell cycle phase by Flow cytometry analysis. (d) H₂O₂ (30 μmol/L) resulted in slight C-28/I2 chondrocyte apoptosis by Flow cytometry analysis. (e) The expression of P21 and P16 was increased under H₂O₂. (f). IL-1β and IL-6 expression was increased in the H₂O₂-induced C-28/I2 chondrocyte cell senescence model. Data are expressed as mean ± SD. The asterisk indicates a significant difference (p < 0.05).