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(a) Uridine treatment reduced the ratio of β-gal positive cells. (b) The expression level of P16 and P21 was reduced by uridine treatment. (c) Uridine treatment increased the C-28/I2 chondrocyte cell proliferation. (d) Cell cycle was changed by uridine treatment (n = 5). E. Ki67 was up-regulated by uridine treatment. Data are expressed as mean ± SD. The asterisk indicates a significant difference (p < 0.05).
