Figure 2.
CRO regulated the abnormal CD68, LXR-α, and PPARγ levels in the aorta of mice with AS.
The levels of CD68, LXR-α, and PPARγ in the aorta of mice after being fed with HFD and CRO treatment or not were determined by immunohistochemistry (magnification × 40). ***P < 0.001, vs. Sham; ##P < 0.01, ###P < 0.001, vs. HFD. AS: Atherosclerosis, CRO-L: low dose of Crocin, CRO-H: high dose of Crocin, HFD: high-fat diet; CD68: cluster of difference 68; LXR-α: Liver X Receptor-α; PPARγ: Peroxisome Proliferator-Activated Receptor γ.