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. 2021 Dec 8;21(2):140–151. doi: 10.1080/15384101.2021.2014249

Figure 6.

Figure 6.

Schematic diagram depicting the pathway.

DNA damage activates p53, which induces its targets Killin and p21 expression to lead to p53-mediated G1 arrest. Though inhibition of p21 ubiquitination, Killin upregulates p21 expression. Killin can also induce G1, G2/M, S arrest via directly binding and inhibiting DNA/RNA synthesis.