Figure 5.

The transcriptional response of blood cells to C. auris is dominated by the expression of immune mediators. (a) Expression of human genes encoding immune cell receptors, cytokines or chemokines, or associated with immune cell signaling or effector functions. Gene expression is shown color-coded as log₂FC vs. 0 min and for each time point (15, 30, 60, 120, 240 mpi). More details are given in Table S3. (b) Plasma levels of the pro-inflammatory cytokines IL-1β, IL-6, TNF-α and the chemokine IL-8 240 mpi with C. auris alive or heat-killed (HK) or in an uninfected control sample. n ≥ 5 different donors shown as mean ± SD (c) Expression of selected human cytokines over the time course of C. auris infection. Gene expression is shown as log₂FC vs. 0 min, indicated by color intensity.