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. 2022 Jan 28;12:748403. doi: 10.3389/fonc.2022.748403

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Copyright © 2022 Jiang, Siu, Wang, Leung, Chan, Cheung, Ngan and Chan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PFKFB3 shifts CSC metabolism in ovarian cancer. (A) Relative mRNA expression of PFKFB3 in tumorsphere/monolayer and ALDH+CD44+/ALDH-CD44- cells via qPCR. (B) Protein expression of PFKFB3 in tumorsphere/monolayer and ALDH+CD44+/ALDH-CD44- cells, determined via immunoblotting; Relative PFKFB3 (C) mRNA and (D) protein expression in tumorspheres and ALDH+CD44+ cells transfected with control siRNA or siPFKFB3 duplexes and PFKFB3-overexpressing ALDH-CD44- cells, determined by qPCR and immunoblotting, respectively. (E) Relative lactate production and (F) oxygen consumption rate of PFKFB3-suppressing ALDH+CD44+ cells and PFKFB3-overexpressing ALDH-CD44- cells after 24 h incubation. (n = 3; *p < 0.05, **p < 0.01).