Table 2 Current selective estrogen receptor degraders (SERDs).
| SERD Substance Code (Name) | Name of study programme | References |
|---|---|---|
| * New class of SERD (Proteolysis Targeting Chimera, PROTAC) ** New class of SERD (Selective Estrogen Receptor Covalent Antagonist; SERCA) | ||
| LSZ102 | unknown | 53 |
| G1T48 (rintodestrant) | PRESERVE | 54 , 55 |
| RAD1901 (elacestrant) | EMERALD | 14 , 56 |
| GDC-9545 (giredestrant) | …ERA (coopERA, lidERA, perseveERA) | 57 , 58 , 59 |
| SAR439859 (amcenestrant) | AMEERA | 60 , 61 , 62 |
| AZD9833 (camizestrant) | SERENA | 63 |
| LY3484356 (imlunestrant) | EMBER | 64 , 65 , 66 |
| Zn-c5 | unknown | 67 |
| D-0502 | unknown | 68 |
| ARV-471* | unknown | 15 |
| H3B-5942** | unknown | 69 |