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. 2022 Feb 11;82(2):139–180. doi: 10.1055/a-1671-2158
No. Recommendations/Statements GoR LoE Sources
8.10.
modified 2021
Consensus-based recommendation
In stage IA1 without any risk factors, treatment must be administered as follows:
Surgery:
  • Lymph-node removal is not indicated.

  • If family planning has been completed, or if the patient wishes greater certainty:

    • Simple hysterectomy.

  • If the patient wishes to have children:

    • Conization (within healthy margins) with cervical curettage.

  • If there are positive margins in the conization specimen (R1):

    • Repeat conization, or

    • Trachelectomy (within healthy margins, with prophylactic permanent cerclage).

  • Following successful pregnancy:

    • Secondary hysterectomy is possible, particularly if there is persistent HPV, abnormal Pap findings, if the patient wishes maximum safety, or if the cervix is difficult or impossible to assess.

Radio(chemo)therapy:
  • Not indicated.

EC
8.11.
new 2021
Consensus-based recommendation
In stage IA1 with lymphatic infiltration (L1), treatment must be administered as follows:
Surgery:
  • Sentinel lymphadenectomy is indicated.

  • If family planning has been completed, or if the patient wishes greater certainty:

    • Simple hysterectomy.

  • If the patient wishes to have children:

    • Conization (within healthy margins) with cervical curettage.

  • If there are positive margins in the conization specimen (R1):

    • Repeat conization, or

    • Trachelectomy (within healthy margins, with prophylactic permanent cerclage).

  • Following successful pregnancy:

    • Secondary hysterectomy is possible, particularly if there is persistent HPV, abnormal Pap findings, if the patient wishes maximum safety, or if the cervix is difficult or impossible to assess.

Radio(chemo)therapy:
  • Not indicated.

EC
8.12.
modified 2021
Consensus-based recommendation
In stage IA1 with at least two risk factors,
and stage IA2 with up to one risk factor,
treatment should be administered as follows:
Surgery:
  • If the patient does not wish to have children and if she wants to be particularly safe and has histologically negative lymph nodes (pelvic) after surgical staging with SNB:

    • Hysterectomy (with bilateral adnexectomy if appropriate), without resection of the parametria (Piver I)

  • If the patient wishes to have children and has negative lymph nodes after surgical staging with SNB:

    • Conization with cervical curettage or

    • Radical trachelectomy with prophylactic permanent cerclage.

  • If there are sentinel lymph nodes affected by tumor, or there are pelvic lymph-node metastases:

    • Para-aortic lymphadenectomy (surgical staging).

  • In premenopausal patients:

    • Ovariopexy to maintain intrinsic ovarian function.

  • If there are macroscopically tumor-affected pelvic and/or para-aortic lymph nodes:

    • Surgical removal before radio(chemo)therapy.

  • After successful pregnancy:

    • Secondary hysterectomy, particularly when there is persistent HPV infection, Pap abnormalities, if the patient wants greater safety, and if the cervix can only be assessed to a limited extent or not at all.

Radio(chemo)therapy:
  • If there is histological evidence of pelvic and/or para-aortic lymph-node metastases or there are several risk factors:

    • R(CH)T in the histologically confirmed area of spread.

EC
8.13.
modified 2021
Consensus-based recommendation
In stage IA2 with at least two risk factors, treatment should be administered as follows:
Surgery (preserving fertility is not possible) with SNB:
  • With negative lymph nodes (pelvic) after surgical staging:

    • Radical hysterectomy (with bilateral adnexectomy if appropriate), with resection of the parametria (Piver II)

  • If there are sentinel lymph nodes affected by tumor or if there are pelvic lymph-node metastases:

    • Additional para-aortic lymphadenectomy (surgical staging).

  • In premenopausal patients:

    • Ovariopexy to maintain intrinsic ovarian function.

  • If there are macroscopically tumor-affected pelvic and/or para-aortic lymph nodes:

    • Surgical removal of these before radio(chemo)therapy.

Radio(chemo)therapy:
  • If there is histological evidence of pelvic and/or para-aortic lymph-node metastases or there are several risk factors:

    • R(CH)T in the histologically confirmed area of spread.

EC