Figure 4.

Hypoxia-derived risk score acts as a robust and independent risk factor for GBM prognosis. (a) Kaplan-Meier curves were conducted for externally verifying the difference in OS between high- and low-risk groups in CGGA dataset. (b) ROC curves of 3-, 4-, and 5-year survival were depicted for assessment of the predictive performance for GBM prognosis in the CGGA dataset. (c) Time-independent ROC curves were established for hypoxia-derived risk score, age, sex, and tumor purity in TCGA dataset. (d, e) Uni- and multivariate cox regression analysis was adopted for evaluating the associations of hypoxia-derived risk score, age, sex, and tumor purity with GBM prognosis in TCGA dataset. (f) Correlation between hypoxia-derived risk score and age across GBM patients was presented in TCGA dataset. (g) Hypoxia-derived risk score was compared in female and male patients in TCGA dataset. (h) Association of hypoxia-derived risk score with tumor purity was carried out in TCGA dataset. (i–k) Kaplan-Meier curves were conducted for assessing the OS differences in each subgroup stratified by hypoxia-derived risk score, age, sex, and tumor purity (TMP) in TCGA dataset.