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. 2022 Feb 12;304:66–77. doi: 10.1016/j.jad.2022.02.025

Table 2.

Risk of Bias Assessments using the RoB 2 tool or the ROBINS-I tool.

Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I)
Study Name Domain 1: Risk of bias due to confounding Domain 2: Risk of bias in selection of participants into the study Domain 3: Risk of bias in classification of interventions Domain 4: Risk of bias due to deviations from intended interventions Domain 5: Risk of bias due to missing data Domain 6: Risk of bias in measurement of outcomes Domain 7: Risk of bias in selection of the reported result Overall risk of bias
Ford et al. (2019) Low N/A N/A N/A Low Low Low Low
Hussar et al. (1971) Serious Low Low Low Low Low Low Serious
Friedman et al. (1967) Moderate Low Low Low Low Low Low Moderate
(Solomon et al., 1968) Moderate Low Low Low Low Low Low Moderate
Wang et al. (2016) Moderate N/A N/A N/A Low Low Low Moderate
Vaughan et al. (1949) Moderate Low Low Low Low Low Low Moderate
Armstrong-Esther et al. (1978) Low Low Low Low Low Low Low Low
Taylor et al. (2017) Low Low Low Low Moderate Low Low Low
Dopp et al. (2007) Moderate Low Low Low Low Low Low Low
Kosor Krnic et al. (2007) Moderate Low Low Low Low Low Low Low
Risk of Bias 2 (RoB 2)
Domain 1: Risk of bias arising from the randomization process Domain 2: Risk of bias due to deviations from the intended intervention (effect of assignment to intervention) Domain 3: Risk of bias due to missing outcome data Domain 4: Risk of bias in measurement of the outcome Domain 5: Risk of bias in selection of the reported result Overall risk of bias
Cassiers et al. (2019) Low Low Low Low Low Low
Niemegeers et al. (2016) Low Low Low Low Low Low

Note: N/A refers to domains that were not applicable for that study.