Table 3.
Antiviral Drugs | Dosage forms | Dose | Indications | Benefits | Drawbacks |
---|---|---|---|---|---|
Remdesivir | Solution/Powder | Intravenous/200 mg loading dose, followed by 100 mg once daily for 5–10 days for adults | COVID-19 patients of ≥12 years requiring hospitalization | It reduces the requirement of high level of respiratory (oxygen) support. There is no evidence of resistance development upon its long term exposure | Signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat were noticed during or after its injection |
Favipiravir | Film-coated tablet | Oral/1800 mg/dose twice a day on the first day; followed by 800 mg/dose twice a day for 7–10 days for adults | COVID-19 | Favipiravir provides multiple treatment benefits, demonstrated by faster time to clinical cure, and significantly delayed the need for supportive oxygen therapy | It has poor pharmacokinetic profile |
Molnupiravir | 800 mg PO q12hr for 5 days | Emergency use authorization issued for treatment of mild-to-moderate (COVID-19) in adults testing positive for severe acute respiratory syndrome (SARS-CoV-2) virus, and who are at high risk for progression to severe COVID-19 (hospitalization or death) after COVID-19 | It has quick onset of action, a wide therapeutic window, excellent tolerance with a good safety profile, fewer adverse reactions and good tolerability due to its better bioavailability; quick clearance of SARs-COV-2; & no accumulative toxicity | Emergency use | |
Galidesivir | Galidesivir an adenosine nucleoside analog phase I clinical trials, including against SARS COV-2 Its IM injection or IV infusion is safe and generally well tolerated |
In-vitro and in-vivo activities of Galidesivir are restricted to RNA of human public health concern. Its trial has not been designed or sized to demonstrate clinical efficacy |