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. 2022 Feb 12;14:100116. doi: 10.1016/j.medntd.2022.100116

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© 2022 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 4 — Micro/nano devices based on isothermal amplification methods for point-of-care testing applicaitons. (a) A microfluidic device using LAMP for sample-in-result-out detection of infectious pathogens [141]; Reproduced with permission. Copyright 2020, Royal Society of Chemistry. (b) A centrifugal direct microfluidic chip based on RPA for multiplexed and sensitive detection of pathogenic bacteria [139]; Reproduced with permission. Copyright 2020, Royal Society of Chemistry. (c) Workflow of a point-of-care multiplexed microfluidic device integrated with a smartphone for detecting live virus from nasal swab media [144]; Reproduced with permission. Copyright 2020, Royal Society of Chemistry. (d) A low-cost isothermal amplification platform with multiplexed microwell array biochip for rapid and visualized detection of SARS-CoV-2 [145]; Reproduced with permission. Copyright 2020, AAAS. (e) A microfluidic origami-paper-based device based on LAMP for low-cost and multiplexed detection of malaria [147]; Reproduced with permission. Copyright 2020, Wiley-VCH. (f) A paper-based device with functions of nucleic acid extraction, isothermal amplification and visual detection [148]; Reproduced with permission. Copyright 2020, Royal Society of Chemistry. (g) ID NOW instrument for point-of-care testing of SARS-CoV-2 [93].