Table 1.
GWAS and fine-mapping analyses across ten autoimmune disorders. All studies were performed on European subjects except for SLE, which combined European and East Asian subjects in the fine-mapping analysis
| Disorder | Abbreviation | Heritability (CIs) (c) | GWAS | Fine-mapping | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| # case | # loci | PMID | # case | # loci | 1-SNP set | 5-SNP set | Method | PMID | |||
| Ankylosing spondylitis | AS | 0.97 (0.92–0.99) | 10,417 | 48 | 26974007 | 10,619 | 28 | 0 | - | PICS | 25363779 |
| Autoimmune thyroid disease | THY | 0.79 | 30,234 | 93 | 32581359 | 2,747 | 10 | 0 | - | PICS | 25363779 |
| Celiac disease | CeD | 0.57 (0.32–0.93) | 12,041 | 40 | 22057235 | 12,041 | 40 | 1 | - | PICS | 25363779 |
| Inflammatory bowel diseases—Crohn’s disease (a) | IBD—CD | 1.00 (0.34–1.00) | 25,042 | 240 | 28067908 | 20,155 | 94 | 18 | 42 | - | 28658209 |
| Inflammatory bowel diseases—Ulcerative colitis (a) | IBD—UC | 0.67 ± 0.13 | 15,191 | ||||||||
| Multiple sclerosis | MS | 0.25 (0.00–0.88) | 47,429 | 233 | 31604244 | 14,498 | 87 | 2 | - | PICS | 25363779 |
| Psoriasis | PSOR | 0.66 (0.52–0.77) | 19,032 | 63 | 28537254 | 10,588 | 36 | 7 | - | PICS | 25363779 |
| Rheumatoid arthritis | RA | 0.68 (0.55–0.79) | 22,628 | 121 | 33310728 | 11,475 | 46 | 0 | 5 | ABF | 30224649 |
| Systemic lupus erythematosus | SLE | 0.66 | 11,283 | 132 | 33536424 | 11,283 | 132 | 5 | 17 | PAINTOR | 33536424 |
| Type 1 diabetes (b) | T1D | 0.88 (0.78–0.94) | 11,644 | 51 | 25751624 | 9,334 | 49 | 1 | 10 | ABF | 30224649 |
aCD and UC are two subtypes of IBD and are often analyzed together for their extensively shared genetic architecture
bThe GWAS study included both case–control and family samples
cHeritability estimates compiled from multiple sources with detailed provided in Maria Gutierrez-Arcelus et al. Nature Reviews Genetics 2016 (PMID: 26907721)