Table 1.
Lapcin activity against human cell lines.
| Cancer type | IC50 (nM) | ||
|---|---|---|---|
| Cell line | Lapcin | Etoposide | Camptothecin |
| Colon cancer | |||
| HT29 | 0.516 | 9,610 | 22.3 |
| Colo205 | 0.504 | >54,400 | 95.7 |
| HCT116 | 923 | >54,400 | 129 |
| SW480 | 37.2 | 26,900 | 284 |
| Breast cancer | |||
| MCF 7 | 35.1 | 333 | >29,200 |
| HCC1806 | 212 | 3,330 | 19.6 |
| Lung cancer | |||
| A549 | 2.66 | 79.9 | 17.6 |
| NCI-H1299 | 0.0168 | 716 | 15.0 |
| NCI-H226 | 241 | 217 | 28.5 |
| Other | |||
| Hela (Cervical) | 0.986 | 1,510 | 62.6 |
| U2OS (Bone) | 1.29 | 1,840 | 172 |
| Normal cell | |||
| HEK293 | 48.4 | 729 | 19.2 |
Note: IC50s were rounded to three significant figures. n = 3 biologically independent cells.