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. 2022 Feb 11;12:2322. doi: 10.1038/s41598-022-05857-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Progenitor and migration markers are associated with GRP78⁺ cells in High-risk individuals with B-ALL. (A,B) Patients were classified by Standard risk and High risk and according to the stage of B-cell development markers, and the percentage of sGRP78⁺ cells was assessed. Statistical analysis was performed by two-tailed Mann–Whitney U test, *p < 0.01, **p < 0.05. (C–G) CD34, CD38, CD10, CD19 and CXCR4 were measured on GRP78⁺ cells by flow cytometry and the percentages are depicted for both high and standard-risk patients. Statistical analysis was performed by Mann–Whitney U test, *p < 0.01, **p < 0.05, ***p < 0.001.