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. 2022 Feb 11;12:2322. doi: 10.1038/s41598-022-05857-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dimensional reduction of flow cytometry data from Standard and High-risk LLA patients. (A) Cluster organization and heatmap of the median marker intensities of the lineage markers and sGRP78. (B) TSNE based on the 10 clusters obtained by FlowSOM comparing LLA Standard-risk group (Standard-risk) against LLA High-risk group (High-risk). (C) TSNE showed the expression level of each marker separated by group risk. Heat maps were built by using Cytometry dATa anALYSis Tools (CATALYST). https://bioconductor.org/packages/3.10/bioc/html/CATALYST.html.