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. 2022 Feb 11;12:2322. doi: 10.1038/s41598-022-05857-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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sGRP78⁺ CXCR4⁺ cells are present in peripheral blood of pediatric individuals with newly diagnosed B-ALL. (A) Live cells from peripheral blood of B-ALL patients and controls (CTL) were stained with anti-CD45 and anti-GRP78. (B) Statistical representation of GRP78⁺ cells in B-ALL patients and controls. (C) Percentages of GRP78⁺ cells in high and standard risk are depicted. (D) Live cells from peripheral blood were stained with anti-CD45, anti-GRP78 and anti-CXCR4. The plots of a Standard risk patient (left) and High risk patient (right) are depicted. (E) Percentages of sGRP78⁺ CXCR4⁺ cells in high and standard risk in peripheral blood. Data are the medians plus ranks. Statistical analysis was performed by two-tailed Mann–Whitney U test, **p < 0.01, ***p < 0.001.