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Design and SARs of dual-target inhibitors of BET and HDAC based on the pharmacophore fusion strategy (3,5-dimethylisoxazole skeleton and indole skeleton). Protein is represented by light blue surface, with compound-contacting residues indicated by yellow sticks. The compound is shown in sticks and colored according to the atom type (C, light blue; N, blue; O, red). Black dashed line = hydrogen bond
